To be a little more specific, I just needed to do a release on a project, and had to [ultimately] use the Chromium-based Edge to do it.

Two things popped out as not working - at all:
1) nothing I could enter as a "tag" was considered acceptable, even though I already had 5 prior releases, and so have a clue on how to specify a tag, and
2) the drag-and-drop of binary artifacts just didn't work - nothing got uploaded, and in fact there was no status indications of any kind after doing the "drop"
On SM, the usual for me: Win 10 "20H2", 64-bit, with NoScript not blocking anything for GitHub, and the same for UBlock Origin (disabled for the site)... even though a fully enabled "UB:O" was being used with Edge.
If anyone wanted to look at this, just use a GitHub project login and try even the above two steps for making a "dummy" release (you don't actually need to complete anything, of course) - thanks!
And, ha - I actually remembered to check the "Error Console"

Timestamp: 8/9/2020, 3:34:38 PM
Error: TypeError: this.toggleAttribute is not a function
Source File: https://github.githubassets.com/assets/ ... 5d5ba97.js
Line: 16
... which doesn't look all that interesting, and Edge had no issues at all (just as a comparison, not trying to rank anything).